VDR is a gene that encodes for a protein which functions as a receptor for vitamin D that regulates bone formation and calcium absorption. A variant of the gene, rs2228570 (FokI polymorphism) is associated with lower bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern, as well as the time on-and-off occupancy of VDRE between the two components. It is also affected by chromosomal locations and binding preferences for certain hormones. Studies of microarrays in human cells have revealed that more than 100 genes are enriched with a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) could be an archive of data and documents relevant to legal transactions, business or other proceedings. Viewing, downloading or printing are restricted. It makes use of a central server as well as an extranet connection that is an Internet connection with restricted access to allow controlled login times when users can view the data and documents.
Companies and investment banks that are involved in mergers and acquisitions are among the most common users of a VDR. They need an efficient and gescheftmarketing.de/2021/09/01/what-is-the-best-school-coding-platform/ secure platform to share information with potential buyers or investors in a transparent way and the process of due diligence can require massive quantities of data. Life science companies also use VDRs for everything from clinical trials results to HIPAA compliance documents.